Redox signalling and cardioprotection: translatability and mechanism.

  title={Redox signalling and cardioprotection: translatability and mechanism.},
  author={Pasquale Pagliaro and Claudia Penna},
  journal={British journal of pharmacology},
  volume={172 8},
The morbidity and mortality from coronary artery disease (CAD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of culprit coronary arteries. Although it is mandatory to reperfuse the ischaemic territory as soon as possible, paradoxically this leads to additional myocardial injury, namely ischaemia/reperfusion (I/R) injury, in which redox stress plays a pivotal role and for which no effective therapy is… CONTINUE READING
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