Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes.

@article{Sderberg2007RedoxsignalingTI,
  title={Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes.},
  author={Anita S{\"o}derberg and Ana Mar{\'i}a Barral and Mats S{\"o}derstr{\"o}m and Birgitta Sander and Anders Ros{\'e}n},
  journal={Free radical biology & medicine},
  year={2007},
  volume={43 1},
  pages={90-9}
}
Hydrogen peroxide is known to be involved in redox signaling pathways that regulate normal processes and disease progression, including cytokine signaling, oxidative stress, and cancer. In studies on immune surveillance against cancer, hydrogen peroxide was found to disrupt cytotoxic T-cell function, thus contributing to tumor escape. In this study, secretion of TNF-containing vesicles of rab9+ endosomal origin, termed exosomes, was investigated using GFP-TNF constructs. We observed a polarized… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Respiratory burst oxidases: the engines of ROS signaling.

Current opinion in plant biology • 2011
View 11 Excerpts
Highly Influenced

Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2018

Functions of Cancer-Derived Extracellular Vesicles in Immunosuppression

Archivum Immunologiae et Therapiae Experimentalis • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…