Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes.

  title={Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes.},
  author={Anita S{\"o}derberg and Ana Mar{\'i}a Barral and Mats S{\"o}derstr{\"o}m and Birgitta Sander and Anders Ros{\'e}n},
  journal={Free radical biology & medicine},
  volume={43 1},
Hydrogen peroxide is known to be involved in redox signaling pathways that regulate normal processes and disease progression, including cytokine signaling, oxidative stress, and cancer. In studies on immune surveillance against cancer, hydrogen peroxide was found to disrupt cytotoxic T-cell function, thus contributing to tumor escape. In this study, secretion of TNF-containing vesicles of rab9+ endosomal origin, termed exosomes, was investigated using GFP-TNF constructs. We observed a polarized… CONTINUE READING
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