Redox signaling in acute oxygen sensing

@inproceedings{Gao2017RedoxSI,
  title={Redox signaling in acute oxygen sensing},
  author={Lin Gao and Patricia Gonz{\'a}lez-Rodr{\'i}guez and Patricia Ortega-S{\'a}enz and Jos{\'e} L{\'o}pez-Barneo},
  booktitle={Redox biology},
  year={2017}
}
Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular… CONTINUE READING

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