Redox-sensitive inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma

@inproceedings{Chitra2013RedoxsensitiveIO,
  title={Redox-sensitive inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma},
  author={M Jaya Chitra and Anup Bhattacharya and M Chhabinath and {\'A}l},
  year={2013}
}
P cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the heat shock protein 90 (Hsp90), making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 along with direct hindrance of its chaperonic activity by a carbazole alkaloid (CM-5), as a strategic therapeutic in pancreatic cancer. CM-5 exhibited anti-proliferative activity against… CONTINUE READING