Redox self-sufficient whole cell biotransformation for amination of alcohols.

@article{Klatte2014RedoxSW,
  title={Redox self-sufficient whole cell biotransformation for amination of alcohols.},
  author={Stephanie Klatte and Volker F Wendisch},
  journal={Bioorganic & medicinal chemistry},
  year={2014},
  volume={22 20},
  pages={5578-85}
}
Whole cell biotransformation is an upcoming tool to replace common chemical routes for functionalization and modification of desired molecules. In the approach presented here the production of various non-natural (di)amines was realized using the designed whole cell biocatalyst Escherichia coli W3110/pTrc99A-ald-adh-ta with plasmid-borne overexpression of genes for an l-alanine dehydrogenase, an alcohol dehydrogenase and a transaminase. Cascading alcohol oxidation with l-alanine dependent… CONTINUE READING