Redox-responsive mesoporous silica nanoparticles: a physiologically sensitive codelivery vehicle for siRNA and doxorubicin.

@article{Ma2014RedoxresponsiveMS,
  title={Redox-responsive mesoporous silica nanoparticles: a physiologically sensitive codelivery vehicle for siRNA and doxorubicin.},
  author={Xing Ma and Cathleen Teh and Quan Zhang and Parijat Borah and Cleo S N Choong and Vladimir Korzh and Yanli Zhao},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 5},
  pages={707-22}
}
AIMS Efficient siRNA/drug codelivery carriers can offer great promises to cancer treatment on account of synergistic effect provided from cancer-associated gene and anticancer drugs. In this work, a redox-responsive drug/siRNA codelivery vehicle based on mesoporous silica nanoparticles was fabricated to simultaneously deliver siRNA and doxorubicin (Dox) in vitro and in vivo. RESULTS The nanoparticle surface was functionalized with the adamantane (AD) units. Formation of stable host-guest… CONTINUE READING
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Redox - Responsive Drug Delivery

  • Chung Yen Ang, Si Yu Tan, Yanli Zhao
  • Antioxidants & Redox Signaling
  • 2014

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