Redox-related antimelanoma activity of ATN-224.

Abstract

Melanoma cells characteristically produce increased levels of reactive oxygen species (ROS) because of the metal-binding properties of melanin and loss of structural integrity of the melanosome. Agents that deplete gluthathione or inhibit superoxide dismutase, thereby blocking ROS scavenging mechanisms, may be selectively toxic to melanoma. To determine… (More)
DOI: 10.1097/CMR.0b013e32832c6324

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