Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells.

@article{Lou2008RedoxRO,
  title={Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells.},
  author={Yi-Wei Lou and Yi-yun Chen and Shu-Fan Hsu and R Chen and Chih-Lei Lee and Kay-Hooi Khoo and Nicholas K. Tonks and T Meng},
  journal={The FEBS journal},
  year={2008},
  volume={275 1},
  pages={69-88}
}
The oxidation and inactivation of protein tyrosine phosphatases is one mechanism by which reactive oxygen species influence tyrosine phosphorylation-dependent signaling events and exert their biological functions. In the present study, we determined the redox status of endogenous protein tyrosine phosphatases in HepG2 and A431 human cancer cells, in which reactive oxygen species are produced constitutively. We used mass spectrometry to assess the state of oxidation of the catalytic cysteine… CONTINUE READING
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