Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.

@article{Hitchler2012RedoxRO,
  title={Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.},
  author={Michael J. Hitchler and F E Domann},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 11},
  pages={2178-87}
}
Cancer arises from normal cells that acquire a series of molecular changes; however, the founding events that create the clonogens from which a tumor will arise and progress have been the subject of speculation. Through the efforts of several generations of cancer biologists it has been established that the malignant phenotype is an amalgamation of genetic and metabolic alterations. Numerous theories have suggested that either, or both, of these elements might serve as the impetus for cancer… CONTINUE READING