Redox regulation of sodium and calcium handling.

  title={Redox regulation of sodium and calcium handling.},
  author={Stefan Wagner and Adam G. Rokita and Mark E. Anderson and Lars Siegfried Maier},
  journal={Antioxidants & redox signaling},
  volume={18 9},
SIGNIFICANCE In heart failure (HF), contractile dysfunction and arrhythmias result from disturbed intracellular Ca handling. Activated stress kinases like cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), which are known to influence many Ca-regulatory proteins, are mechanistically involved. RECENT ADVANCES Beside classical activation pathways, it is becoming increasingly evident that reactive oxygen species (ROS) can… CONTINUE READING