Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.

@article{Calabrese2006RedoxRO,
  title={Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.},
  author={Vittorio Calabrese and David Butterfield and Giovanni Scapagnini and Anna Maria Giuffrida Stella and Mahin D. Maines},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 3-4},
  pages={444-77}
}
Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. The major neurodegenerative diseases are all associated with the presence of abnormal proteins. Different integrated responses exist in the brain to detect oxidative stress which is… CONTINUE READING

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