Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma.

@article{Pawate2004RedoxRO,
  title={Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma.},
  author={Siddharama Pawate and Qin Shen and Fan Fan and Narayan R. Bhat},
  journal={Journal of neuroscience research},
  year={2004},
  volume={77 4},
  pages={540-51}
}
Astrocytes and microglia, the two immune-regulatory cells of the central nervous system (CNS), are activated by a variety of pathogens and cytokines to elicit rapid transcriptional responses. This program of activation is initiated by a set of intracellular signaling cascades that includes mitogen-activated protein kinase (MAPK), nuclear factor (NF) kappaB, and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways. This study defines the critical role that NADPH… CONTINUE READING
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