Redox regulation of diaphragm proteolysis during mechanical ventilation.

@article{McClung2008RedoxRO,
  title={Redox regulation of diaphragm proteolysis during mechanical ventilation.},
  author={Joseph M. McClung and Melissa A Whidden and Andreas N. Kavazis and Darin J. Falk and Keith C Deruisseau and Scott K. Powers},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 5},
  pages={R1608-17}
}
Prevention of oxidative stress via antioxidants attenuates diaphragm myofiber atrophy associated with mechanical ventilation (MV). However, the specific redox-sensitive mechanisms responsible for this remain unknown. We tested the hypothesis that regulation of skeletal muscle proteolytic activity is a critical site of redox action during MV. Sprague-Dawley rats were assigned to five experimental groups: 1) control, 2) 6 h of MV, 3) 6 h of MV with infusion of the antioxidant Trolox, 4) 18 h of… CONTINUE READING

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Mechanical ventilation R1616 ANTIOXIDANTS ALTER PROTEIN BALANCE DURING ATROPHY AJP-Regul

  • RA Shanely, D Van Gammeren, +4 authors SK. Powers
  • Integr Comp Physiol
  • 2008
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