Redox regulation of chemokine receptor expression.

  title={Redox regulation of chemokine receptor expression.},
  author={Alessandra Saccani and Simona Saccani and Simone Orlando and Marina Sironi and S Bernasconi and Pietro Ghezzi and Alberto Mantovani and Antonio Sica},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 6},
Cytokines and reactive oxygen intermediates (ROI) are frequent companions at sites of acute inflammation. We have shown previously that in human monocytes, bacterial lipopolysaccharide, IL-1, and tumor necrosis factor-alpha induce a rapid down-regulation of the monocyte chemotactic protein-1 receptor CCR2 (CC chemokine receptor-2). These stimuli also induce production of ROI. In this paper, we investigate the influence of antioxidants and/or ROI on chemokine-receptor expression. In human… CONTINUE READING