Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.

@article{Sun1999RedoxRO,
  title={Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.},
  author={Q A Sun and Yiqin Wu and Francesca Zappacosta and K T Jeang and Byeong Jae Lee and Dolph Lee Hatfield and Vadim N. Gladyshev},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 35},
  pages={24522-30}
}
The intracellular generation of reactive oxygen species, together with the thioredoxin and glutathione systems, is thought to participate in redox signaling in mammalian cells. The activity of thioredoxin is dependent on the redox status of thioredoxin reductase (TR), the activity of which in turn is dependent on a selenocysteine residue. Two mammalian TR isozymes (TR2 and TR3), in addition to that previously characterized (TR1), have now been identified in humans and mice. All three TR… CONTINUE READING
76 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.

Redox Signaling and Thioredoxin Reductases

  • P. Y. Gasdaska, M. M. Berggren, M. J. Berry, G. Powis
  • FEBS Lett. 442,
  • 1999

Similar Papers

Loading similar papers…