Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling.

@article{Das2006RedoxRO,
  title={Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling.},
  author={Samarjit Das and Hajime Otani and Nilanjana Maulik and Dipak Kumar Das},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={41 2},
  pages={248-55}
}
A recent study documented reactive oxygen species (ROS), generated through NADPH oxidase by angiotensin II (Ang II) with the activation of NADPH oxidase subunits, p22phox and gp91phox, to be responsible for the preconditioning effect of Ang II. The present study was designed to determine if similar to ischemic preconditioning (PC), mitogen-activated protein (MAP) kinases are also involved in Ang II PC of the heart. Isolated working rat hearts were perfused for 15 min with KHB (Krebs-Henseleit… CONTINUE READING

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Isolated working rat hearts were perfused for 15 min with KHB ( Krebs - Henseleit bicarbonate ) buffer containing Ang II in the absence or presence of an Erk ( 1/2 ) inhibitor , PD 098059 , a p38MAPK inhibitor , SB 202190 , a JNK inhibitor , SP 600125 or a ROS scavenger , N - acetyl cysteine ( NAC ) .
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