Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.

Abstract

4-Hydroxy-2-nonenal (4-HNE), one of the major biologically active aldehydes formed during inflammation and oxidative stress, has been implicated in a number of cardiovascular and pulmonary disorders. 4-HNE has been shown to increase vascular endothelial permeability; however, the underlying mechanisms are unclear. Hence, in the current study, we tested our… (More)

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Cite this paper

@article{Usatyuk2006RedoxRO, title={Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.}, author={Peter V. Usatyuk and Narasimham L. Parinandi and Viswanathan Natarajan}, journal={The Journal of biological chemistry}, year={2006}, volume={281 46}, pages={35554-66} }