Redox-regulating sirtuins in aging, caloric restriction, and exercise.

@article{Radk2013RedoxregulatingSI,
  title={Redox-regulating sirtuins in aging, caloric restriction, and exercise.},
  author={Zsolt Rad{\'a}k and Erika Koltai and Albert Taylor and Mitsuru Higuchi and Shuzo Kumagai and Hideki Ohno and Sataro Goto and Istvan Boldogh},
  journal={Free radical biology & medicine},
  year={2013},
  volume={58},
  pages={
          87-97
        }
}
The consequence of decreased nicotinamide adenine dinucleotide (NAD(+)) levels as a result of oxidative challenge is altered activity of sirtuins, which, in turn, brings about a wide range of modifications in mammalian cellular metabolism. Sirtuins, especially SIRT1, deacetylate important transcription factors such as p53, forkhead homeobox type O proteins, nuclear factor κB, or peroxisome proliferator-activated receptor γ coactivator 1α (which controls the transcription of pro- and antioxidant… CONTINUE READING
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