Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.

@article{Carrero2000RedoxregulatedRO,
  title={Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.},
  author={Paloma Carrero and Koji Okamoto and Pascal Coumailleau and Susan M O'Brien and Hiroyuki Tanaka and Lorenz Poellinger},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 1},
  pages={
          402-15
        }
}
Hypoxia-inducible factor 1alpha (HIF-1alpha) functions as a transcription factor that is activated by decreased cellular oxygen concentrations to induce expression of a network of genes involved in angiogenesis, erythropoiesis, and glucose homeostasis. Here we demonstrate that two members of the SRC-1/p160 family of transcriptional coactivators harboring histone acetyltransferase activity, SRC-1 and transcription intermediary factor 2 (TIF2), are able to interact with HIF-1alpha and enhance its… CONTINUE READING
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