Redox reactions of the α-synuclein-Cu(2+) complex and their effects on neuronal cell viability.

  title={Redox reactions of the α-synuclein-Cu(2+) complex and their effects on neuronal cell viability.},
  author={Chengshan Wang and Lin Liu and Lin Zhang and Yong Peng and Feimeng Zhou},
  volume={49 37},
α-Synuclein (α-syn), a presynaptic protein believed to play an important role in neuropathology in Parkinson's disease (PD), is known to bind Cu(2+). Cu(2+) has been shown to accelerate the aggregation of α-syn to form various toxic aggregates in vitro. Copper is also a redox-active metal whose complexes with amyloidogenic proteins/peptides have been linked to oxidative stress in major neurodegenerative diseases. In this work, the formation of the Cu(2+) complex with α-syn or with an N-terminal… CONTINUE READING


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