Redox reactions of hemoglobin and myoglobin: biological and toxicological implications.

  title={Redox reactions of hemoglobin and myoglobin: biological and toxicological implications.},
  author={Abdu I Alayash and Rakesh P Patel and Robert E. Cashon},
  journal={Antioxidants & redox signaling},
  volume={3 2},
Direct cytotoxic effects associated with hemoglobin (Hb) or myoglobin (Mb) have been ascribed to redox reactions (involving either one- or two-electron steps) between the heme group and peroxides. These interactions are the basis of the pseudoperoxidase activity of these hemoproteins and can be cytotoxic when reactive species are formed at relatively high concentrations during inflammation and typically lead to cell death. Peroxides relevant to biological systems include hydrogen peroxide… CONTINUE READING


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