Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital.

Abstract

Induction of phase 2 enzymes is a major strategy in chemoprotection against cancer. Inducers belong to nine different chemical classes. In this study we found that a measure of the tendency of 30 plant phenylpropenoids and synthetic analogs to release electrons correlates linearly with their potency in inducing the activity of NAD(P)H:quinone reductase… (More)

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@article{Zoete2004RedoxRO, title={Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital.}, author={Vincent Zoete and Michel Roug{\'e}e and Albena T. Dinkova-Kostova and Paul Talalay and Ren{\'e} Victor Bensasson}, journal={Free radical biology & medicine}, year={2004}, volume={36 11}, pages={1418-23} }