Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis.

@article{Perluigi2009RedoxPI,
  title={Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis.},
  author={Marzia Perluigi and Rukhsana Sultana and Giovanna Cenini and Fabio di Domenico and Maurizio Memo and William M. Pierce and Raffaella Coccia and David Butterfield},
  journal={Proteomics. Clinical applications},
  year={2009},
  volume={3 6},
  pages={682-693}
}
Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress including in those brain areas directly involved in the neurodegenerative process of Alzheimer's disease (AD). Lipid peroxidation directly damages membranes and also generates a number of secondary biologically active products (toxic aldehydes)that are capable of easily attacking lipids, proteins, and DNA. Accumulating evidence has demonstrated regionally increased brain lipid peroxidation in patients… CONTINUE READING
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