Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes.

@article{Punj2003RedoxPI,
  title={Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes.},
  author={Vasu Punj and Ananda M. Chakrabarty},
  journal={Cellular microbiology},
  year={2003},
  volume={5 4},
  pages={225-31}
}
Mammalian cell mitochondria are believed to have prokaryotic ancestry. Mitochondria are not only the powerhouse of energy generation within the eukaryotic cell but they also play a major role in inducing apoptotic cell death through release of redox proteins such as cytochrome c and the apoptosis-inducing factor (AIF), a flavoprotein with NADH oxidase activity. Recent evidence indicates that some present day prokaryotes release redox proteins that induce apoptosis in mammalian cells through… CONTINUE READING