Redox processes controlling the biogenesis of c-type cytochromes.

@article{Bonnard2010RedoxPC,
  title={Redox processes controlling the biogenesis of c-type cytochromes.},
  author={G{\'e}raldine Bonnard and Vincent Corvest and Etienne H Meyer and Patrice Paul Hamel},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={13 9},
  pages={1385-401}
}
In mitochondria, two mono heme c-type cytochromes are essential electron shuttles of the respiratory chain. They are characterized by the covalent attachment of their heme C to a CXXCH motif in the apoproteins. This post-translational modification occurs in the intermembrane space compartment. Dedicated assembly pathways have evolved to achieve this chemical reaction that requires a strict reducing environment. In mitochondria, two unrelated machineries operate, the rather simple System III in… CONTINUE READING