Redox outside the box: linking extracellular redox remodeling with intracellular redox metabolism.

@article{Banerjee2012RedoxOT,
  title={Redox outside the box: linking extracellular redox remodeling with intracellular redox metabolism.},
  author={Ruma Banerjee},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 7},
  pages={4397-402}
}
Aerobic organisms generate reactive oxygen species as metabolic side products and must achieve a delicate balance between using them for signaling cellular functions and protecting against collateral damage. Small molecule (e.g. glutathione and cysteine)- and protein (e.g. thioredoxin)-based buffers regulate the ambient redox potentials in the various intracellular compartments, influence the status of redox-sensitive macromolecules, and protect against oxidative stress. Less well appreciated… CONTINUE READING
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