Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

@inproceedings{Icimoto2017RedoxMO,
  title={Redox modulation of thimet oligopeptidase activity by hydrogen peroxide},
  author={Marcelo Yudi Icimoto and Juliana C. Ferreira and C{\'e}sar Henrique Yokomizo and Larissa Valdemarin Bim and Alyne Marem and Joyce Meire Gilio and Vitor Oliveira and Iseli Lourenço Nantes},
  booktitle={FEBS open bio},
  year={2017}
}
Thimet oligopeptidase (EC 3.4.24.15, TOP) is a cytosolic mammalian zinc protease that can process a diversity of bioactive peptides. TOP has been pointed out as one of the main postproteasomal enzymes that process peptide antigens in the MHC class I presentation route. In the present study, we describe a fine regulation of TOP activity by hydrogen peroxide… CONTINUE READING