Redox modulation of integrin [correction of integin] alpha IIb beta 3 involves a novel allosteric regulation of its thiol isomerase activity.

@article{Walsh2004RedoxMO,
  title={Redox modulation of integrin [correction of integin] alpha IIb beta 3 involves a novel allosteric regulation of its thiol isomerase activity.},
  author={Geraldine M Walsh and David Sheehan and Anthony L Kinsella and Niamh Moran and Sarah O'Neill},
  journal={Biochemistry},
  year={2004},
  volume={43 2},
  pages={473-80}
}
The molecular mechanisms involved in regulating the activation-dependent conformational switch in integrins are not known although recent evidence suggests that integrins are a direct target for redox modulation. We have identified an endogenous integrin thiol isomerase activity that may be responsible for regulating integrin activation states. The purpose of this study was to examine the effects of redox conditions elicited by nitric oxide and glutathione on the thiol isomerase activity of the… CONTINUE READING
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