Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function.

  title={Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function.},
  author={Vittorio Calabrese and Claudia Colombrita and Rukhsana Sultana and Giovanni Scapagnini and Menotti Calvani and David Allan Butterfield and Anna Maria Giuffrida Stella},
  journal={Antioxidants \& redox signaling},
  volume={8 3-4},
There is significant evidence to show that aging is characterized by a stochastic accumulation of molecular damage and by a progressive failure of maintenance and repair processes. Protective mechanisms exist in the brain which are controlled by vitagenes and include members of the heat shock system, heme oxygenase-I, and Hsp70 as critical determinants of brain stress tolerance. Given the broad cytoprotective properties of the heat shock response, molecules inducing this defense mechanism… 

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