Redox modulation of contractile function in respiratory and limb skeletal muscle

@article{Smith2006RedoxMO,
  title={Redox modulation of contractile function in respiratory and limb skeletal muscle},
  author={Melissa A. Smith and Michael B. Reid},
  journal={Respiratory Physiology & Neurobiology},
  year={2006},
  volume={151},
  pages={229-241}
}
For the last half century, scientists have studied the biological importance of free radicals in respiratory and limb muscles. We now know that muscle fibers continually produce both reactive oxygen species (ROS) and nitric oxide (NO) and that both cascades play critical roles in contractile regulation. Under basal conditions, muscle-derived ROS and NO exert opposing effects. Low-level ROS activity is an essential part of the homeostatic milieu and is required for normal force production… CONTINUE READING

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