Redox modulation of HMGB1-related signaling.

Abstract

SIGNIFICANCE In the cells' nuclei, high-mobility group box protein 1 (HMGB1) is a nonhistone chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 acts as a danger molecule with properties of a proinflammatory cytokine. It can be actively secreted from myeloid cells or passively leak from any type of injured, necrotic… (More)
DOI: 10.1089/ars.2013.5179

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