Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death.

@article{Belevych2009RedoxMO,
  title={Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death.},
  author={Andriy E Belevych and Dmitry Terentyev and Serge Viatchenko-Karpinski and Radmila Terentyeva and Arun Raghav Mahankali Sridhar and Yoshinori Nishijima and Lance D. Wilson and Arturo J. Cardounel and Kenneth R Laurita and Cynthia A. Carnes and George E. Billman and S{\'a}ndor Gyorke},
  journal={Cardiovascular research},
  year={2009},
  volume={84 3},
  pages={387-95}
}
AIMS Although cardiac alternans is a known predictor of lethal arrhythmias, its underlying causes remain largely undefined in disease settings. The potential role of, and mechanisms responsible for, beat-to-beat alternations in the amplitude of systolic Ca(2+) transients (Ca(2+) alternans) was investigated in a canine post-myocardial infarction (MI) model of sudden cardiac death (SCD). METHODS AND RESULTS Post-MI dogs had preserved left ventricular (LV) function and susceptibility to… CONTINUE READING

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