Redox mechanisms of cardiomyocyte mitochondrial protection

  title={Redox mechanisms of cardiomyocyte mitochondrial protection},
  author={Raquel R. Bartz and Hagir B. Suliman and Claude A. Piantadosi},
  booktitle={Front. Physiol.},
Oxidative and nitrosative stress are primary contributors to the loss of myocardial tissue in insults ranging from ischemia/reperfusion injury from coronary artery disease and heart transplantation to sepsis-induced myocardial dysfunction and drug-induced myocardial damage. This cell damage caused by oxidative and nitrosative stress leads to mitochondrial protein, DNA, and lipid modifications, which inhibits energy production and contractile function, potentially leading to cell necrosis and/or… CONTINUE READING
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