Redox manipulation using the thiol-oxidizing agent diethyl maleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model.

Abstract

Manipulation of the intracellular redox state has been shown to alter cell activation pathways with resultant changes in cellular function. Previous studies have suggested that thiol oxidation, using the glutathione-depleting agent diethyl maleate (DEM), was able to inhibit endothelial cell activation. We hypothesized that this agent might exert beneficial… (More)

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@article{Jones1999RedoxMU, title={Redox manipulation using the thiol-oxidizing agent diethyl maleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model.}, author={J. J. Jones and J. Fan and Avery B Nathens and Andr{\'a}s Kapus and Mark Shekhman and J C Marshall and Jean C Parodo and Ori D. Rotstein}, journal={Hepatology}, year={1999}, volume={30 3}, pages={714-24} }