Redox imbalance in the critically ill.

@article{Gutteridge1999RedoxII,
  title={Redox imbalance in the critically ill.},
  author={John M C Gutteridge and Jamie R. Mitchell},
  journal={British medical bulletin},
  year={1999},
  volume={55 1},
  pages={49-75}
}
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae: septic shock, the systemic inflammatory response syndrome (SIRS) and the acute respiratory distress syndrome (ARDS). Clinically, sepsis/SIRS and ARDS are characterised by disordered vascular control, manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy; and pulmonary hypertension… CONTINUE READING

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Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
Thus , our own and other groups have shown that the vascular pathology of sepsis / SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen ( ROS ) and reactive nitrogen species ( RNS ) which modulate inflammatory cell adhesion and cause direct injury to endothelium ( Fig . 1 ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae : septic shock , the systemic inflammatory response syndrome ( SIRS ) and the acute respiratory distress syndrome ( ARDS ) .
Clinically , sepsis / SIRS and ARDS are characterised by disordered vascular control , manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy ; and pulmonary hypertension .
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