Redox imbalance and biochemical changes in cancer.

  title={Redox imbalance and biochemical changes in cancer.},
  author={Tonia C Jorgenson and Weixiong Zhong and Terry D. Oberley},
  journal={Cancer research},
  volume={73 20},
For this article, we explore a hypothesis involving the possible role of reduction/oxidation (redox) state in cancer. We hypothesize that many modifications in cellular macromolecules, observed in cancer progression, may be caused by redox imbalance. Recent biochemical data suggest that human prostate cancer cell lines show a redox imbalance (oxidizing) compared with benign primary prostate epithelial cells; the degree of oxidation varied with aggressive behavior of each cell line. Our recent… CONTINUE READING
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The biology of cancer

  • RA Weinberg
  • 2007
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