Redox factor-1 mediates NF-kappaB nuclear translocation for LPS-induced iNOS expression in murine macrophage cell line RAW 264.7.

@article{Song2008RedoxFM,
  title={Redox factor-1 mediates NF-kappaB nuclear translocation for LPS-induced iNOS expression in murine macrophage cell line RAW 264.7.},
  author={Ju Dong Song and Sang Kwon Lee and Kang Mi Ja Kim and Jong Won Kim and Jong Min Kim and Young Hyun Yoo and Young Chul Park},
  journal={Immunology},
  year={2008},
  volume={124 1},
  pages={58-67}
}
Redox-sensitive transcriptional regulator redox factor-1 (Ref-1) is induced by oxidative stress and protects cells against it. However, the function of Ref-1 in regulating nitric oxide (NO) synthesis in macrophages has not been defined. We investigated the role of Ref-1 related to the regulation of NO synthesis in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. LPS stimulates the up-regulation and nuclear translocation of Ref-1 in macrophages. Importantly, Ref-1-deficient… CONTINUE READING

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