Redox-directed cancer therapeutics: molecular mechanisms and opportunities.

  title={Redox-directed cancer therapeutics: molecular mechanisms and opportunities.},
  author={Georg Thomas Wondrak},
  journal={Antioxidants & redox signaling},
  volume={11 12},
Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target identification, and mechanisms of action of experimental redox chemotherapeutics with a focus on pro- and antioxidant redox modulators now in advanced phases of preclinal and… CONTINUE READING
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