Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts☆

@inproceedings{Uchida2013RedoxderivedDM,
  title={Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts☆},
  author={Koji Uchida},
  booktitle={Redox biology},
  year={2013}
}
Endogenous electrophiles, such as α,β-unsaturated aldehydes and ketones generated during lipid peroxidation, exhibit a facile reactivity with proteins, generating a variety of intra and intermolecular covalent adducts. It has been postulated that these host-derived, modified proteins with electrophiles, which constitute the products of diverse classes of oxidative reactions, represent damage-associated molecular patterns (DAMPs). The DAMPs, that occur in vivo, can be a ligand of multiple… CONTINUE READING
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