Redox control of catalysis in ATP-citrate lysate from rat liver.

Abstract

In thiol redox buffers at pH 8.0, rat liver ATP-citrate lyase is in equilibrium between an oxidised inactive form and a reduced active form. The reduced enzyme is inactivated by oxidised glutathione (GSSG) at a rate of 45 min-1.M-1 and the oxidised enzyme is activated by reduced glutathione (GSH) at a rate of 3.2 min-1.M-1. At redox equilibrium, the enzyme… (More)

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@article{Wells1992RedoxCO, title={Redox control of catalysis in ATP-citrate lysate from rat liver.}, author={Timothy Wells and Barbara Saxty}, journal={European journal of biochemistry}, year={1992}, volume={204 1}, pages={249-55} }