Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest.

@article{Lu2007RedoxCO,
  title={Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest.},
  author={Qi Lu and Frances L. Jourd'heuil and David Jourd'heuil},
  journal={Journal of cellular physiology},
  year={2007},
  volume={212 3},
  pages={827-39}
}
Redox regulation of cell cycle progression during nitric oxide (NO) mediated cytostasis is not well-understood. In this study, we investigated the role of the intracellular antioxidant glutathione (GSH) in regulating specific signaling events that are associated with NO-mediated cell cycle arrest. Manipulation of intracellular GSH content through pharmacological inhibition of glutamate-cysteine ligase (GCL) indicated that GSH depletion potentiated nitrosative stress, DNA damage, phosphorylation… CONTINUE READING