Redox conformation changes in refined tuna cytochrome c.

  title={Redox conformation changes in refined tuna cytochrome c.},
  author={Tatsuya Takano and Richard E. Dickerson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 11},
Tuna ferrocytochrome c and ferricytochrome c have been refined independently at high resolution (1.5 A and 1.8 A) to crystallographic residual errors of 17.3% and 20.8%, respectively. Small but significant conformational differences are seen surrounding a buried water molecule that is hydrogen bonded to Asn-52, Tyr-67, and Thr-78. In the oxidized state, this water molecule is 1.0 A closer to the heme and the heme has moved 0.15 A out of its heme crevice; both changes lead to a more polar… CONTINUE READING

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