Redox buffering by melanin and Fe(II) in Cryptococcus neoformans.

  title={Redox buffering by melanin and Fe(II) in Cryptococcus neoformans.},
  author={Eric S. Jacobson and Jae D. Hong},
  journal={Journal of bacteriology},
  volume={179 17},
Melanin is a fungal extracellular redox buffer which, in principle, can neutralize antimicrobial oxidants generated by immunologic effector cells, but its source of reducing equivalents is not known. We wondered whether Fe(II) generated by the external ferric reductase of fungi might have the physiologic function of reducing fungal melanin and thereby promoting pathogenesis. We observed that exposure of a melanin film electrode to reductants decreased the open-circuit potential (OCP) and… CONTINUE READING