Redox biology of the intestine.

  title={Redox biology of the intestine.},
  author={Magdalena L. Circu and Tak Yee Aw},
  journal={Free radical research},
  volume={45 11-12},
The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/TrxSS) redox couples play important roles in preserving tissue redox homeostasis, metabolic functions, and cellular integrity. Control of the thiol-disulfide status at the luminal… CONTINUE READING