Redox biochemistry of hydrogen sulfide.

@article{Kabil2010RedoxBO,
  title={Redox biochemistry of hydrogen sulfide.},
  author={Omer Kabil and Ruma Banerjee},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 29},
  pages={21903-7}
}
H(2)S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of gamma-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H(2)S production in the vasculature. However, patients with inherited deficiency in gamma-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples… CONTINUE READING
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