• DOI:10.1089/15230860050192332
• Corpus ID: 37503639

Redox aspects of signaling by catecholamines and their metabolites.

@article{Smythies2000RedoxAO,
  title={Redox aspects of signaling by catecholamines and their metabolites.},
  author={John Smythies},
  journal={Antioxidants \& redox signaling},
  year={2000},
  volume={2 3},
  pages={
          575-83
        }
}

• J. Smythies
• Published 2000
• Biology
• Antioxidants & redox signaling

This review covers certain novel aspects of catecholamine signaling in neurons that involve redox systems and synaptic plasticity. The redox hypothesis suggests that one important factor in neurocomputation is the formation of new synapses and the removal of old ones (synaptic plasticity), which is modulated in part by the redox balance at the synapse between reactive oxygen species (ROS) (such as hydrogen peroxide and the nitric oxide radical) and neuroprotective antioxidants (such as ascorbate, glutathione, and catecholamines). Catecholamines, in particular dopamine, which signals positive reinforcement, may play a key role in this activity. Dopamine has powerful antioxidant properties by several separate mechanisms-direct ROS scavenging, activation of the synthesis of antioxidant proteins, and possibly via dismuting complexes with iron inside endosomes or in catecholaminergic synaptic vesicles. This may contribute to synaptic growth and reinforcement-directed learning. On the other hand, catecholamines are easily oxidized to toxic quinones on the neuromelanin pathway. This might contribute under certain circumstances to synaptic deletion. Evidence is presented that abnormalities in this system may contribute to the pathogenesis of Parkinson's disease and schizophrenia.