Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

@article{Valko2015RedoxAN,
  title={Redox- and non-redox-metal-induced formation of free radicals and their role in human disease},
  author={M. Valko and K. Jomov{\'a} and C. Rhodes and K. Ku{\vc}a and K. Musilek},
  journal={Archives of Toxicology},
  year={2015},
  volume={90},
  pages={1-37}
}
Abstract Transition metal ions are key elements of various biological processes ranging from oxygen formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict limits through tightly regulated mechanisms of uptake, storage and secretion. The breakdown of metal ion homeostasis can lead to an uncontrolled formation of reactive oxygen species, ROS (via the Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause… Expand
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