Redox Regulation of Protein Tyrosine Phosphatase 1 B by Manipulation of Dietary Selenium Affects the Triglyceride Concentration in Rat Liver 1 , 2

Protein tyrosine phosphatase 1B (PTP1B) is a key enzyme in the counter-regulation of insulin signaling and in the stimulation of fatty acid synthesis. Selenium (Se), via the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), is involved in the removal of H2O2 and organic peroxides, which are critical compounds in the modulation of… (More)