Redox Regulation of Pka Signaling : Kinase versus Phosphatase Inactivation

  title={Redox Regulation of Pka Signaling : Kinase versus Phosphatase Inactivation},
  author={Kenneth M Humphries and Juniper K. Pennypacker and Susan S. Taylor},
Many components of cellular signaling pathways are sensitive to regulation by oxidation and reduction. Previously, we described the inactivation of cAMP dependent protein kinase (PKA) by direct oxidation of a reactive cysteine in the activation loop of the kinase. In the present study, we demonstrate that in Hela cells PKA activity follows a biphasic response to thiol oxidation. Under mild oxidizing conditions, or short exposure to oxidants, forskolin stimulated PKA activity is enhanced. This… CONTINUE READING


Publications referenced by this paper.

Bioorg Med Chem 5, 1739-1750 at B om eical Lirary

J. E. Sheppeck, 2nd, C. M. Gauss, A. R. Chamberlin
U C S D on July 11, • 1997

Similar Papers

Loading similar papers…