Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

@inproceedings{Kim2018RedoxRO,
  title={Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence},
  author={Young-Mee Kim and Seock-Won Youn and Varadarajan Sudhahar and Archita Das and Reyhaan Chandhri and Henar Cuervo Grajal and Junghun Kweon and Silvia Leanhart and Lianying He and P{\'e}ter T. T{\'o}th and Jan Kitajewski and Jalees Rehman and Yisang Yoon and Jaehyung Cho and Tohru Fukai and Masuko Ushio-Fukai},
  booktitle={Cell reports},
  year={2018}
}
Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that PDIA1… CONTINUE READING

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